Sr. Scientist/Principal Scientist, Pharmacokinetics

We are seeking a highly motivated and skilled PK scientist to join our dynamic and growing Translational Sciences Team. The successful candidate will act as a PK lead for discovery and early development programs, providing PK/PD and mechanistic modeling insights by integrating ADME and PK/PD data to drive decision making from drug candidate selection to clinical development.

Requirements

• Serve as the PK lead on multidisciplinary teams, partnering with chemistry, platform biology, computational biology, clinical, regulatory, and CMC to advance discovery and early development programs.
• Apply modeling and simulation approaches (PK/PD, mechanistic, PBPK, QSP) to enable nonclinical to clinical translation, guide dose selection, and inform clinical design.
• Design and oversee ADME and PKPD studies, both internally and with CROs, to support drug candidate selection and regulatory submissions.
• Conduct NCA to calculate PK and TK parameters in compliance with GLP and applicable regulatory guidelines to support IND and other regulatory submissions.
• Prepare high-quality study summaries, technical reports, and input for regulatory documents (e.g. IND, IB, BB, etc)
• Integrate DMPK and pharmacology data to build quantitative frameworks to inform structure-activity relationships, target validation, and molecule design.
• Contribute to program strategy by identifying key risks with quantitative understanding.
• Stay current with emerging trends in translational modeling and predictive ADME to help implement innovative tools and best practices.

Benefits

• Comprehensive and competitive benefits package
• 401(k) with competitive company match
• Medical, dental, vision, life insurance
• Health and dependent care FSA accounts
• HSA/HRA accounts with company contributions