Director, Quantitative Lead

Praxis is hiring a Director, Quantitative Lead to guide statistical design, quantitative decision-making, and modeling across clinical development programs.

Requirements

• Lead statistical design for clinical studies
• Author or oversee SAPs and associated analysis specifications
• Guide quantitative strategy across exploratory, interim, and confirmatory study phases
• Lead exposure-efficacy and exposure-safety analyses using clinical exposure metrics
• Apply statistical modeling approaches in R or Python
• Develop simulation-based scenarios to support dose selection and benefit-risk assessments
• Oversee blinded exploratory analyses using ARR and other metadata-driven layers
• Guide Statistical Data Scientists in the implementation, visualization, and reproducible execution of exploratory models
• Ensure quantitative analyses are implemented within reproducible, metadata-driven frameworks
• Partner with Statistical Data Scientists and programming teams to translate quantitative intent into executable specifications
• Support validation, traceability, and audit readiness of all quantitative workflows
• Provide quantitative interpretation for study teams, governance discussions, and regulatory documents
• Review CSRs and contribute to regulatory responses involving quantitative rationale
• Mentor Statistical Data Scientists and Statistical Programmers on modeling, statistical methodology and interpretation.

Benefits

• 99% of the premium paid for medical, dental and vision plans
• Company-paid life insurance, AD&D, disability benefits
• Voluntary plans to personalize coverage
• Matching dollar-for-dollar up to 6% on eligible 401(k) contributions
• Long-term stock incentives and ESPP
• Discretionary quarterly bonus
• Flexible wellness benefit
• Generous PTO
• Paid holidays and company-wide shutdowns