Associate Director/Director, Biochemistry

We are seeking a highly motivated Biochemist to join our drug discovery team in Watertown, Massachusetts. The candidate will design and execute experiments to support 1-2 programs at any one time, combining enzymology and biochemistry expertise with quantitative modeling, strong experimental skills in the lab, and an ability to communicate and collaborate across multi-functional teams.

Requirements

• PhD in Biochemistry, Enzymology, Chemical Biology, Biophysics or closely related discipline with 6+ years of biotech/pharma industry experience or MS with 10+ years relevant industry experience.
• Experience in small molecule drug discovery, specifically biochemical assay development and characterization of small molecule inhibitors and protein-ligand binding interactions.
• Training and hands on expertise in mechanistic enzymology, kinetics, binding assays, and mechanistic deconvolution with a proven track record of high impact applications to drug discovery.
• Expertise deriving and validating mechanistic models based on a merger of biochemical, biophysical and structural data including expertise with global fitting and kinetic and steady state modeling.
• Track record of translating mechanistic insight into practical strategies for hit identification, hit triage, lead selection, SAR interpretation, or assay design.
• Experience designing and optimizing a wide array of steady-state and pre-steady-state biochemical assays, both enzymatic and binding, such as FP, TR-FRET, and bead-based.
• Attention to detail and good troubleshooting and problem-solving skills.
• Strong written and oral communication skills, excellent interpersonal skills, with demonstrated ability to work collaboratively on multidisciplinary teams.