Principal Scientist, Computational Chemistry

Frontier Medicines is seeking a highly motivated individual to fill the position of Principal Scientist, Computational Chemistry. The successful candidate will play a leading role in developing medicinal chemistry optimization strategies for key drug discovery programs.

Requirements

• Design, execute, and analyze computational chemistry studies using a wide range of ligand-based, structure-based, and physics-based modeling techniques.
• Partner closely with medicinal chemists and biologists to develop and refine structure–activity relationships (SAR), optimize molecular properties, and guide design hypotheses.
• Contribute to project strategy and decision-making across all discovery stages, including target assessment, hit identification, lead optimization, and development candidate nomination.
• Champion innovative computational tools and workflows, identify and implement emerging technologies that enhance Frontier’s CADD capabilities – specifically with an eye to the applicability to the covalent domain.
• Work closely and partner with the AI team to develop and integrate novel AI applications into daily drug design workflows
• Communicate scientific results, design rationales, and strategic insights to multidisciplinary teams and senior leadership.

Benefits

• Health Care Plan (Medical, Dental & Vision)
• Retirement Plan (401k, IRA)
• Life Insurance (Basic, Voluntary & AD&D)
• Paid Time Off (Vacation, Sick & Public Holidays)
• Family Leave (Maternity, Paternity)
• Short Term & Long Term Disability
• Training & Development
• Free Food & Snacks
• Wellness Resources
• Stock Option Plan