Principal Scientist, Computational Chemistry

Frontier Medicines is seeking a Principal Scientist, Computational Chemistry to develop medicinal chemistry optimization strategies for key drug discovery programs. The successful candidate will review experimental results, develop SAR hypotheses, and make design suggestions to improve the profiles of small molecule drug candidates.

Requirements

• Design, execute, and analyze computational chemistry studies using a wide range of ligand-based, structure-based, and physics-based modeling techniques.
• Partner closely with medicinal chemists and biologists to develop and refine structure–activity relationships (SAR), optimize molecular properties, and guide design hypotheses.
• Contribute to project strategy and decision-making across all discovery stages, including target assessment, hit identification, lead optimization, and development candidate nomination.
• Champion innovative computational tools and workflows, identify and implement emerging technologies that enhance Frontier’s CADD capabilities – specifically with an eye to the applicability to the covalent domain.
• Work closely and partner with the AI team to develop and integrate novel AI applications into daily drug design workflows
• Communicate scientific results, design rationales, and strategic insights to multidisciplinary teams and senior leadership.

Benefits

• Health Care Plan (Medical, Dental & Vision)
• Retirement Plan (401k, IRA)
• Life Insurance (Basic, Voluntary & AD&D)
• Paid Time Off (Vacation, Sick & Public Holidays)
• Family Leave (Maternity, Paternity)
• Short Term & Long Term Disability
• Training & Development
• Free Food & Snacks
• Wellness Resources
• Stock Option Plan